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Infectious Disease: Hepatitis B

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Characteristics, management and outcomes of patients with acute liver failure admitted to Australasian intensive care units.
CONCLUSION: POD is the major cause of ALF in Australian and New Zealand liver transplant centres and is a unique and separate form of ALF. It has a much lower associated mortality and treatment with liver transplantation than non-POD ALF. Non-POD patients have a poor prognosis in the absence of transplantation. PMID: 31462206 [PubMed - in process]
Source: Critical Care and Resuscitation - August 31, 2019 Category: Intensive Care Tags: Crit Care Resusc Source Type: research

Hepatitis B Vaccination, Screening, and Linkage to Care: Best Practice Advice From the American College of Physicians and the Centers for Disease Control and Prevention.
Abstract Background: Vaccination, screening, and linkage to care can reduce the burden of chronic hepatitis B virus (HBV) infection. However, recommendations vary among organizations, and their implementation has been suboptimal. The American College of Physicians' High Value Care Task Force and the Centers for Disease Control and Prevention developed this article to present best practice statements for hepatitis B vaccination, screening, and linkage to care. Methods: A narrative literature review of clinical guidelines, systematic reviews, randomized trials, and intervention studies on hepatitis B vaccinatio...
Source: Annals of Internal Medicine - November 21, 2017 Category: Internal Medicine Authors: Abara WE, Qaseem A, Schillie S, McMahon BJ, Harris AM, High Value Care Task Force of the American College of Physicians and the Centers for Disease Control and Prevention Tags: Ann Intern Med Source Type: research

The hepatitis B care cascade using administrative claims data, 2016.
CONCLUSIONS: We identified gaps in linkage to care and treatment in commercially insured adults with CHB. PMID: 32835460 [PubMed - as supplied by publisher]
Source: The American Journal of Managed Care - July 31, 2020 Category: Health Management Authors: Harris AM, Osinubi A, Nelson NP, Thompson WW Tags: Am J Manag Care Source Type: research

Point-of-Care HIV Diagnostics for Low Resource Regions: Interview with Jesse Lehga, VP at Diagnostics for the Real World
DRW (Diagnostics for the Real World), a company with headquarters in San Jose, California, and Cambridge, United Kingdom, has developed the SAMBA II, a point-of-care diagnostic device for the detection of infectious diseases, including HIV and HCV, f...
Source: Medgadget - February 27, 2020 Category: Medical Devices Authors: Conn Hastings Tags: Diagnostics Exclusive Medicine Pathology Source Type: blogs

STI Guideline Updates for Pediatric Hospitalists
PHM Session: 2021 Sexually Transmitted Infection (STI) Guideline Updates: What the Pediatric Hospitalist Needs to Know Presenters: Jason Zucker, MD, Columbia University, New York, and Candice McNeil, MD, MPH, Atrium Health Wake Forest Baptist, Winston-Salem, N.C. As the assistant director of the New York City STD/HIV Prevention Training Center and co-medical director of the Southeast STD/HIV Prevention Training Center, Drs. Zucker and McNeil shared their expertise on this ever-evolving topic. As of 2020, there were more than 2 million cases of chlamydia and gonorrhea, about 130,000 cases of syphilis, and a 235% increase in...
Source: The Hospitalist - September 23, 2022 Category: Hospital Management Authors: Lisa Casinger Tags: Adolescent Medicine Clinical Guidelines Diagnostic Education HIV Lifestyle Pediatrics STIs Source Type: research

Praluent, the Next Expensive "Game Changer," Blockbuster," "New Hope," - But Not Yet Shown to Benefit Patients
ConclusionsThe NEJM study was accompanied by an editorial by Stone and Lloyd-Jones(2) which documented that drugs previously shown to lower cholesterol were never proved to do any good for patients, and concluded,it would be premature to endorse these drugs for widespread use before the ongoing randomized trials, appropriately powered for primary end-point analysis and safety assessment, are available. After an FDA advisory committee recommended approval of aliromucab and another PCSK9 inhibitor in June, 2015, John Mandrola entitled a Medscape article,Dear FDA: Resist the Urge on PCSK9 DrugsHis reasons included lack o...
Source: Health Care Renewal - August 5, 2015 Category: Health Management Tags: aliromucab evidence-based medicine health care prices manipulating clinical research PCSK9 inhibitor Praluent Regeneron Sanofi-Aventis Source Type: blogs

Survey of Immunization Practices in Patients With Inflammatory Bowel Disease Among Pediatric Gastroenterologists
Conclusions: There is practice variation among pediatric gastroenterologists in assessment of immunizations in patients with inflammatory bowel disease, including the specific vaccines assessed, and timing and method of assessment. Inability to coordinate care, access immunization records, and offer vaccines through their medical practice are barriers to adhering to immunization guidelines.
Source: Journal of Pediatric Gastroenterology and Nutrition - July 1, 2015 Category: Gastroenterology Tags: Original Articles: Gastroenterology Source Type: research

Barriers to Linkage to Care for Hepatitis B Virus Infection: A Qualitative Analysis in Burkina Faso, West Africa.
Abstract Hepatitis B virus (HBV) infection is a critical global health problem. The World Health Organization (WHO) has recently developed a global elimination strategy for HBV infection. Increasing access to screening, liver assessment, and antiviral treatment are crucial steps in achieving this goal. Little is known, however, about obstacles to linkage to care in low- and middle-income countries. Using a grounded theory approach, this qualitative study sought to characterize the diagnostic itineraries of people with chronic HBV infection in Burkina Faso, a west African country with high HBV prevalence, to identi...
Source: The American Journal of Tropical Medicine and Hygiene - December 6, 2016 Category: Tropical Medicine Authors: Giles-Vernick T, Hejoaka F, Sanou A, Shimakawa Y, Bamba I, Traoré A Tags: Am J Trop Med Hyg Source Type: research

Quiz Page March 2013: A Critically Ill Infant With Sepsis, Respiratory Failure, and Anasarca
A 1-month-old full-term male infant presented with decreased activity, poor appetite, and abdominal distension. Serologic testing during the first trimester of pregnancy showed that the mother was nonreactive upon rapid plasma reagin (RPR) testing, was rubella immune, and had negative results for hepatitis B and C, toxoplasma, and human immunodeficiency virus (HIV) tests. Vaginal/cervical specimens were negative for chlamydia, gonorrhea, and streptococcus group B. On admission, the infant's weight was 3.6 kg, height was 48.5 cm, rectal temperature was 94.7°F, heart rate was 150 beats/min, respiratory rate was 68 breaths/m...
Source: American Journal of Kidney Diseases - February 18, 2013 Category: Urology & Nephrology Authors: Juan C. Kupferman, Eric D. Spitzer, M. Barry Stokes Source Type: research

Transcript of Dr. Bihari Video
00:00 to 02.26—Dr. Bihari gives his background and credentials. Dr. Bihari: My medical training started at Harvard Medical School. I graduated in 1957. Then I trained in Internal Medicine at one of the Harvard teaching hospitals in Boston, Beth Israel, and then in Neurology at Massachusetts General in Boston. Then I went to the National Institutes of Health for two years doing brain physiology—brain research. I did another residency training in Psychiatry in New York, at Columbia Presbyterian Medical Center and then, over the following five or six years, I got very involved in working in Drug Addiction. By 1974, I was...
Source: HONEST MEDICINE: My Dream for the Future - May 16, 2011 Category: Consumer Health News Authors: JuliaS1573 at aol.com (Julia Schopick) Tags: Anecdotal Treatments HONEST MEDICINE Integrative Medicine Low Dose Naltrexone Obituaries Source Type: blogs

Some Authoritative Skepticism about the "Triumph" of Sovaldi to Add to Outrage about "Blood Money"
This report just appeared online in JAMA Internal Medicine [Ollendorf DA, Tice JA et al.  The comparative clinical effectiveness and value of simeprevir and sofosbuvir in chronic hepatitis C viral infection.  JAMA Inte Med 2014.  Link here.] The review found again that there were major limitations in the available data, and so much of it was based on a network meta-analysis and simulation studies,The review was limited to patients with genotype 1, 2, and 3 infections, which account for most HCV cases in the United States. At the time of the review, no head-to-head trials of the direct-acting antiviral d...
Source: Health Care Renewal - May 7, 2014 Category: Health Management Tags: evidence-based medicine Gilead health care prices manipulating clinical research pharmaceuticals Sovaldi Source Type: blogs

Nosocomial outbreak of hepatitis B virus infection in a pediatric hematology and oncology unit in South Africa: Epidemiological investigation and measures to prevent further transmission
ConclusionsThe high number of HBeAg positive patients, together with suspected lapses in infection prevention and control measures, are believed to have played a major role in the transmission. Measures implemented to prevent further in‐hospital transmission were successful. On‐going HBV screening and vaccination programs in pediatric hematology and oncology units should become standard of care. Pediatr Blood Cancer © 2015 Wiley Periodicals, Inc.
Source: Pediatric Blood and Cancer - June 5, 2015 Category: Cancer & Oncology Authors: Ané Büchner, Nicolette M. Du Plessis, David T. Reynders, Fareed E. Omar, Simnikiwe H. Mayaphi, Ahmad F. Haeri Mazanderani, Theunis Avenant Tags: Research Article Source Type: research

Not So Wondrous Drugs? - New Warnings about Severe Adverse Effects of New, Heavily Marketed Drugs for Hepatits C,
In conclusion, evidence-based medicine rigorously applied suggests that individual health care and health policy decisions should be driven by the best available evidence, mostly from clinical research, about the benefits and harms of tests, treatments, programs, and so on, in the context of what outcomes matter to patients. The skepticism EBM should engender could lead to health care that is more about patients and their outcomes, and less about ideology, hype, and hucksterism. If only such skepticism were easier to find........APPENDIX - Clinical Research about Hepatitis C TreatmentsStarting in March, 2014, we havep...
Source: Health Care Renewal - October 6, 2016 Category: Health Management Tags: adverse effects clinical trials deception evidence-based medicine Gilead hepatitis C marketing Sovaldi Source Type: blogs